scaffolene ® – medical bioresorbable nonwoven technology

scaffolene ® in regenerative medicine

One key advantage of scaffolene ® technology is the gentle process used for nonwoven production, at low temperature without harmful solvents and polymeric degradation. Therefore it is possible to incorporate thermally unstable active ingredients into the nonwoven. These may include proteins such as growth factors and enzymes, hormones or other bioactive substances. These possibilities open up a wide range of innovative applications in regenerative medicine.

Potential applications include trauma surgery and orthopedics. The efficacy of growth factors such as Bone Morphogenic Proteins (BMP) has already been demonstrated in clinical tests. With scaffolene ® technology, a growth factor can now be incorporated directly into the fibers of the nonwoven. As the nonwoven is fixed in the position required and the enzyme is continuously released by degradation of the fibers, the growth factor remains in place for a defined time.

One key advantage of these nonwovens is their 3D structure. The nonwoven forms a scaffold of fibers which can act as a guiding structure for cellular migration. As the fibers themselves may be enriched with other matrix polymers or additives such as collagen, hydroxyapatite or hyaluronic acid, the cells find substrates which they can use for cellular regeneration. The fibers surround large cavities into which cells penetrate, forming connective tissue. This may be especially important for clinical applications where the objective is to replace soft tissue, bone or cartilage.